The prothrombinase complex can catalyze the activation of prothrombin at a rate 3 x 10 5-fold faster than can Factor Xa alone. Although it has been shown that Factor Xa can activate prothrombin when unassociated with the prothrombinase complex, the rate of thrombin formation is severely decreased under such circumstances.
To produce thrombin, the prothrombinase complex cleaves two peptide bonds in prothrombin, one after Arg 271 and the other after Arg 320. The activation of thrombin is a critical reaction in the coagulation cascade, which functions to regulate hemostasis in the body. The prothrombinase complex catalyzes the conversion of prothrombin (Factor II), an inactive zymogen, to thrombin (Factor IIa), an active serine protease. The complex assembles on negatively charged phospholipid membranes in the presence of calcium ions. Ries’ website.The prothrombinase complex consists of the serine protease, Factor Xa, and the protein cofactor, Factor Va. To learn more about the iFactor Course and “The Top Five Weight Loss Mistakes Everybody Makes,” visit Dr. A gifted communicator, he specializes in helping people make sense of today’s complex medical issues in a way that is clear and understandable. Scott Ries is a board certified Family Medicine and Emergency Medicine physician, and founder of iFactor Health. The bottom line is that mistake is thinking that it’s so simple, ‘All I need to do is count the calories less in, burn more, and I’ll lose weight,’ but it doesn’t work it and frustrates people time and time again.”īy avoiding this common weight loss mistake, we will be well on our way to losing the weight we want, and keeping it off.ĭr. “The net effect is you’re reducing your calorie number, but you can’t burn fat because your iFactor is too high. It doesn’t let you burn the fat that you want to burn.” For example, little packages of chips or cookies that are only 100 hundred calories… the problem is people think, ‘OK I’m only going to eat 100 calories,’ but then you get a big response in your body with, specifically a hormone called insulin, that not only doesn’t let you metabolize it well, it converts that into fat. “They’ve done some studies on those hundred calories packs. Ries points out that cutting back on calories isn’t necessarily the key to effective weight loss. Basically, something’s at work in your body preventing that simple math from working.”ĭr. There’s a problem that’s ubiquitous in our Western culture, in our diet, and that’s this: it’s a high iFactor or elevated insulin resistance. “Little “i” stands for insulin, or more specifically, insulin resistance. Ries says there are other factors involved that are important to consider, including the iFactor. So why doesn’t this simple equation of work for our bodies? Dr. One calorie isn’t the same as another calorie it just won’t work for the long-term.” “ Your weight is not simple math so counting your calories doesn’t work, there are other factors involved. You want to lose weight so you subtract some calories, burn some more, but the problem is it’s wrong.” It sounds very simple like four minus two equals two.
“What I was taught in medical school is that your weight basically is the calories you put in, minus the calories you burn, equals your weight. Ries explains why counting calories is a common mistake that we make when it comes to losing weight. “People oftentimes will say, ‘Ok, I’m going to lose weight so I’m going to count my calories.’ That is actually that one of the top five weight loss mistakes everybody makes: counting your calories.”ĭr. He describes one of the top weight loss mistakes everybody makes. Scott Ries is the founder of iFactor Health. Have you been trying to lose weight for some time and haven’t seen any results? Dr.